INT263692

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Neto1)
Anatomy Link Frequency
neurons 2
dendritic arbors 2
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 36 82.72 Quite High
Pyramidal cell 12 77.20 Quite High
cerebral cortex 3 70.88 Quite High
Central nervous system 9 68.00 Quite High
long-term potentiation 78 66.12 Quite High
nMDA receptor 27 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 18 80.48 Quite High
Cognitive Disorder 24 5.00 Very Low Very Low Very Low
Convulsion 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Helminth Infection 3 5.00 Very Low Very Low Very Low
Influenza Virus Infection 3 5.00 Very Low Very Low Very Low
Contagious Ecthyma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether there was an overall decrease in cell surface expression of NR2A-containing NMDARs in Neto1-null mice, we quantified the abundance of biotinylated cell surface proteins in wild-type and Neto1-null hippocampal slices.
Spec (whether) Negative_regulation (decrease) of Gene_expression (expression) of Neto1-null
1) Confidence 0.43 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
We found that Neto1 immunostaining decorated MAP2 positive dendritic arbors and co-localized with that of PSD-95 (Figure 2B) and NR1 (Figure 2C).
Negative_regulation (decorated) of Gene_expression (immunostaining) of Neto1 in dendritic arbors
2) Confidence 0.43 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.19
Because basal synaptic transmission (Figure 7) and AMPAR-EPSCs (Figure S5) in Neto1-null neurons were not different from wild-type, we interpret the decrease in NMDAR:AMPAR EPSC ratio as indicating that synaptic NMDAR currents were reduced in Neto1-null neurons.
Negative_regulation (reduced) of Gene_expression (neurons) of Neto1-null in neurons
3) Confidence 0.43 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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