INT263704

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2009
Negated 4
Speculated 0
Reported most in Body
Documents 1
Total Number 34
Disease Relevance 1.01
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Neto1)
Anatomy Link Frequency
synapses 6
neurons 4
hippocampus 3
brain 2
tail 1
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 102 100.00 Very High Very High Very High
Hippocampus 408 99.84 Very High Very High Very High
Pyramidal cell 136 99.84 Very High Very High Very High
cerebral cortex 34 99.84 Very High Very High Very High
addiction 34 92.80 High High
antagonist 34 83.28 Quite High
long-term potentiation 884 79.04 Quite High
Glutamate receptor 68 79.04 Quite High
Eae 68 49.00 Quite Low
Neurotransmitter 102 29.00 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 204 97.48 Very High Very High Very High
Cognitive Disorder 272 59.52 Quite High
Sprains And Strains 34 40.48 Quite Low
Convulsion 68 9.16 Low Low
Helminth Infection 34 5.00 Very Low Very Low Very Low
Influenza Virus Infection 34 5.00 Very Low Very Low Very Low
Contagious Ecthyma 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neto1 was prominently expressed in the crude synaptosomal (Figure 2A, lane S2) and PSD fractions, but was absent from the synaptic vesicle fraction (Figure 2A, lane LP2).
Neg (absent) Gene_expression (expressed) of Neto1 in synaptic vesicle
1) Confidence 0.78 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.20
Given that Neto1 is expressed in the CA1 region of the hippocampus (Figure 1C), we studied synaptic transmission and plasticity at Schaffer collateral-CA1 synapses, which are widely used to investigate glutamatergic synaptic physiology [30].
Gene_expression (expressed) of Neto1 in synapses associated with hippocampus
2) Confidence 0.78 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.12 Pain Relevance 0.12
To determine whether there was an overall decrease in cell surface expression of NR2A-containing NMDARs in Neto1-null mice, we quantified the abundance of biotinylated cell surface proteins in wild-type and Neto1-null hippocampal slices.
Gene_expression (expression) of Neto1-null
3) Confidence 0.78 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
Generation of Neto1-Null Mice
Gene_expression (Generation) of Neto1-Null
4) Confidence 0.78 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.12 Pain Relevance 0
In contrast, in Neto1-null synapses the reduction was ?
Gene_expression (synapses) of Neto1-null in synapses
5) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
These findings indicate that tbLTP in Schaffer collateral-CA1 synapses of adult Neto1-null mice is mediated primarily by NR2B-containing NMDARs.
Gene_expression (synapses) of Neto1-null in synapses
6) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
Because basal synaptic transmission (Figure 7) and AMPAR-EPSCs (Figure S5) in Neto1-null neurons were not different from wild-type, we interpret the decrease in NMDAR:AMPAR EPSC ratio as indicating that synaptic NMDAR currents were reduced in Neto1-null neurons.
Gene_expression (neurons) of Neto1-null in neurons
7) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.08 Pain Relevance 0.10
Moreover, in Neto1-null synapses, but not in those of wild-type mice, the component of the NMDAR EPSC resistant to Ro25–6981 (2 ?
Gene_expression (synapses) of Neto1-null in synapses
8) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
We found that Neto1 immunostaining decorated MAP2 positive dendritic arbors and co-localized with that of PSD-95 (Figure 2B) and NR1 (Figure 2C).
Gene_expression (immunostaining) of Neto1 in dendritic arbors
9) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.18
We found no difference between wild-type and Neto1-null mice in latency to find a platform marked with a visible cue (Figure 10A, pretraining), indicating that the lack of Neto1 had no detectable adverse effects on the visual and motor functions required for this task.
Gene_expression (wild-type) of Neto1-null
10) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
In contrast, in the absence of NR2, no association was observed between Neto1-?
Neg (no) Gene_expression (observed) of Neto1
11) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Moreover, Neto1 or Neto1-?
Gene_expression (Moreover) of Neto1
12) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04
Moreover, Neto1 or Neto1-?
Gene_expression (Moreover) of Neto1
13) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04
No differences in the level of biotinylated NR1, NR2A, or NR2B were found in Neto1-null compared with wild-type mice (Figure S4A), indicating that the overall cell surface expression of NMDARs is normal in the hippocampus in the absence of Neto1.
Gene_expression (found) of Neto1-null in hippocampus associated with hippocampus
14) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
Both Neto1+/tlz and Neto1-null animals were normal in overall appearance with no gross morphological abnormalities in the brain.
Gene_expression (tlz) of Neto1 in brain associated with congenital anomalies
15) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.18 Pain Relevance 0.04
Fragments encoding the cytoplasmic region of Neto1 (amino acids 345–533) and the C-terminal mutant ?
Gene_expression (region) of Neto1
16) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Thus, basal NMDAR-mediated, but not AMPAR-mediated, synaptic responses are impaired in CA1 pyramidal neurons in the absence of Neto1.
Neg (absence) Gene_expression (absence) of Neto1 in pyramidal neurons associated with pyramidal cell
17) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.09 Pain Relevance 0.08
No differences in the level of biotinylated NR1, NR2A, or NR2B were found in Neto1-null compared with wild-type mice (Figure S4A), indicating that the overall cell surface expression of NMDARs is normal in the hippocampus in the absence of Neto1.
Neg (absence) Gene_expression (absence) of Neto1 in hippocampus associated with hippocampus
18) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
In contrast, in Neto1-null slices Ro25–6981 led to a ?
Gene_expression (slices) of Neto1-null
19) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.06
Both Neto1+/tlz and Neto1-null animals were normal in overall appearance with no gross morphological abnormalities in the brain.
Gene_expression (animals) of Neto1-null in brain associated with congenital anomalies
20) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.19 Pain Relevance 0.04

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