INT263705

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.62
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1ra) extracellular region (C1ra)
C1ra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 81.08 Quite High
long-term potentiation 26 70.16 Quite High
Glutamate 2 61.08 Quite High
Glutamate receptor 2 53.68 Quite High
Central nervous system 3 47.12 Quite Low
Neurotransmitter 3 31.20 Quite Low
Inflammatory response 4 18.72 Low Low
ischemia 24 5.00 Very Low Very Low Very Low
cva 16 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 81.08 Quite High
Death 28 72.00 Quite High
Myocardial Infarction 98 57.64 Quite High
Coronary Artery Disease 32 56.72 Quite High
Heart Disease 4 55.32 Quite High
Glomerulonephritis 46 54.56 Quite High
Paroxysmal Nocturnal Hemoglobinuria 54 53.76 Quite High
Disease 28 52.00 Quite High
Cv Unclassified Under Development 22 5.00 Very Low Very Low Very Low
Renal Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the complement C1r/C1s, Uegf, Bmp1 (CUB) domain protein neuropilin tolloid-like 1 (Neto1) [6,7], which we have discovered to be an NMDAR-associated protein [8].
C1r Binding (complement) of
1) Confidence 0.36 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.15
Another subunit of C1, C1r, cleaves and activates the third subunit of C1, C1s.
C1r Binding (subunit) of
2) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.33 Pain Relevance 0
In the classical pathway, one of the main complement regulatory proteins is C1 inhibitor (C1-INH), which binds to the C1r:C1s complex and causes it to dissociate from C1q, thus preventing activation of the complement system.
C1r Binding (binds) of
3) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

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