INT263724

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4, Neto1) structural molecule activity (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Dlg4 (Mus musculus)
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 4 65.48 Quite High
long-term potentiation 52 5.00 Very Low Very Low Very Low
Hippocampus 24 5.00 Very Low Very Low Very Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Helminth Infection 2 5.00 Very Low Very Low Very Low
Influenza Virus Infection 2 5.00 Very Low Very Low Very Low
Contagious Ecthyma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the binding of Neto1 to PSD-95 was not required for Neto1 to interact with the NMDAR, and that Neto1 interacts with NMDARs through a PSD-95-independent mechanism.


Neg (not) Positive_regulation (required) of PSD-95 Binding (binding) of Neto1
1) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03
To identify the region of Neto1 that mediates the PSD-95-independent association between Neto1 and NMDARs, we examined the ability of a series of C-terminally deleted Neto1 proteins to co-immunoprecipitate with NMDARs from HEK293 cell lysates.
Positive_regulation (mediates) of PSD-95-independent Binding (association) of Neto1
2) Confidence 0.25 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03

General Comments

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