INT263727

Context Info Confidence 0.18 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.05

cell proliferation (Rasgrf1) cytosol (Rasgrf1) transport (Grin2b) intracellular (Rasgrf1) plasma membrane (Grin2b) embryo development (Grin2b)

Grin2b (Mus musculus) Rasgrf1 (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 52 55.36 Hippocampus 24 5.00 nMDA receptor 18 5.00 Pyramidal cell 8 5.00 Central nervous system 6 5.00 Neurotransmitter 6 5.00 Glutamate receptor 4 5.00 Eae 4 5.00 Glutamate 4 5.00 tetrodotoxin 2 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 16 5.00 Congenital Anomalies 12 5.00 Convulsion 4 5.00 Sprains And Strains 2 5.00 Helminth Infection 2 5.00 Influenza Virus Infection 2 5.00 Contagious Ecthyma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, NR2B but not NR2A interacts with Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1), which is critical for NMDAR-mediated activation of ERK [47].

NR2B Binding (interacts) of Ras-guanine nucleotide-releasing factor 1

1) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03

For example, NR2B but not NR2A interacts with Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1), which is critical for NMDAR-mediated activation of ERK [47].

NR2B Binding (interacts) of Ras-GRF1

2) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03

General Comments

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