INT263738

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.11 Pain Relevance 0.53

peptidase activity (C1ra) extracellular region (C1ra) plasma membrane (Neto1)

C1ra (Mus musculus) Neto1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 6 96.96 nMDA receptor 18 93.64 long-term potentiation 52 81.52 Hippocampus 24 5.00 Pyramidal cell 8 5.00 Neurotransmitter 6 5.00 Glutamate receptor 4 5.00 Eae 4 5.00 Glutamate 4 5.00 tetrodotoxin 2 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 16 54.96 Congenital Anomalies 12 25.00 Helminth Infection 2 25.00 Convulsion 4 5.00 Sprains And Strains 2 5.00 Influenza Virus Infection 2 5.00 Contagious Ecthyma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density.

C1r Binding (complement) of Neto1

1) Confidence 0.42 Published 2009 Journal PLoS Biology Section Abstract Doc Link PMC2652390 Disease Relevance 0.05 Pain Relevance 0.27

Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density.

C1r Binding (complement) of neuropilin tolloid-like 1

2) Confidence 0.42 Published 2009 Journal PLoS Biology Section Abstract Doc Link PMC2652390 Disease Relevance 0.05 Pain Relevance 0.27

General Comments

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