INT263749

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b, Neto1) transport (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
hippocampus 1
Grin2b (Mus musculus)
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 48 95.76 Very High Very High Very High
long-term potentiation 104 91.88 High High
Neurotransmitter 12 82.28 Quite High
Glutamate receptor 8 71.12 Quite High
addiction 4 23.32 Low Low
Glutamate 8 7.76 Low Low
nMDA receptor 36 5.00 Very Low Very Low Very Low
Pyramidal cell 16 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 32 5.00 Very Low Very Low Very Low
Congenital Anomalies 24 5.00 Very Low Very Low Very Low
Convulsion 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Helminth Infection 4 5.00 Very Low Very Low Very Low
Influenza Virus Infection 4 5.00 Very Low Very Low Very Low
Contagious Ecthyma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
NR2B Binding (binds) of Neto1 in hippocampus associated with hippocampus
1) Confidence 0.38 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.12
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2B Spec (might) Binding (bind) of Neto1
2) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
We found that Neto1 interacts with the core NMDAR subunits, NR2A and NR2B, and with the scaffolding protein postsynaptic density-95 (PSD-95).
NR2B Binding (interacts) of Neto1
3) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.18
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2B Spec (might) Binding (bind) of Neto1
4) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox