INT263776

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
synapses 1
Grin1 (Mus musculus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 63 100.00 Very High Very High Very High
depression 68 94.16 High High
Pyramidal cell 6 87.76 High High
Hippocampus 13 51.00 Quite High
addiction 3 34.36 Quite Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 68 94.16 High High
Congenital Anomalies 7 18.96 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Amblyopia 4 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Cataract 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Refractive Errors 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
tbLTP at Schaffer collateral-CA1 synapses is NMDAR-dependent [31].
NMDAR Positive_regulation (dependent) of tbLTP in synapses
1) Confidence 0.17 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.15
Additionally, in rats, NMDAR-dependent LTP can be induced in layers 4 and 3 in vivo following tetanic stimulation of LGN, and this LTP is sufficient to increase the magnitude of visually evoked responses (Heynen & Bear 2001).
NMDAR Positive_regulation (dependent) of LTP associated with long-term potentiation
2) Confidence 0.15 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.17 Pain Relevance 0.39

General Comments

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