INT263787

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.05
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1, Dlg4) structural molecule activity (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
tail 1
GRIN1 (Homo sapiens)
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 22 100.00 Very High Very High Very High
central sensitization 9 88.16 High High
Spinal sensitization 1 73.92 Quite High
Kinase C 18 72.92 Quite High
Glutamate receptor 15 61.60 Quite High
Hyperalgesia 4 49.88 Quite Low
Inflammation 9 49.36 Quite Low
spinal dorsal horn 7 42.24 Quite Low
IPN 9 24.44 Low Low
Neuropathic pain 4 10.76 Low Low
Disease Link Frequency Relevance Heat
Nociception 26 54.52 Quite High
Hyperalgesia 5 49.88 Quite Low
INFLAMMATION 9 49.36 Quite Low
Inflammatory Pain 9 24.44 Low Low
Neuropathic Pain 4 10.76 Low Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the binding of Neto1 to PSD-95 was not required for Neto1 to interact with the NMDAR, and that Neto1 interacts with NMDARs through a PSD-95-independent mechanism.


NMDA Binding (interacts) of PSD-95-independent
1) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03
To identify the region of Neto1 that mediates the PSD-95-independent association between Neto1 and NMDARs, we examined the ability of a series of C-terminally deleted Neto1 proteins to co-immunoprecipitate with NMDARs from HEK293 cell lysates.
NMDA Binding (association) of PSD-95-independent
2) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03
Binding of the C-terminal tail of Stargazin to PDZ domains of a number of synaptic scaffolding proteins, such as PSD-95 (an interacting protein associated with NR2 subunits of the NMDA receptors) may mediate the synaptic targeting of surface AMPA receptors [56].
NMDA Binding (associated) of PSD-95 in tail associated with nmda receptor
3) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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