INT2638

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.13
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 100.00 Very High Very High Very High
Analgesic 1 80.64 Quite High
anesthesia 16 76.64 Quite High
Inflammation 19 54.72 Quite High
cytokine 3 47.88 Quite Low
peptic ulcer disease 3 35.28 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 84 100.00 Very High Very High Very High
Pneumoperitoneum 44 100.00 Very High Very High Very High
Atherosclerosis 66 99.72 Very High Very High Very High
Disease 32 96.72 Very High Very High Very High
Coronary Artery Disease 23 95.32 Very High Very High Very High
Hepatitis C Virus Infection 3 93.76 High High
Gallstones 12 93.44 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 93.12 High High
Cardiovascular Disease 21 91.88 High High
Targeted Disruption 3 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PON1 activity is geneticly regulated and varies widely among populations [9].
Regulation (regulated) of PON1
1) Confidence 0.59 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.43 Pain Relevance 0.03
Several factors like nutritional, pharmacological, genetic and infectious processes have been demonstrated to modulate PON1 levels [9].
Regulation (modulate) of PON1
2) Confidence 0.59 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.18 Pain Relevance 0
To assess the possible influence of other drugs and chemicals on the metabolic degradation of aspirin in man, their effect on the serum aspirin esterase activity was determined in vitro.
Regulation (effect) of aspirin esterase associated with aspirin
3) Confidence 0.53 Published 1979 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 488131 Disease Relevance 0 Pain Relevance 0.30
The aim of the present study was to evaluate the association between serum PON-1 activities and CIMT values in patients with H. pylori.
Regulation (values) of PON-1
4) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 0.91 Pain Relevance 0
In addition, no significant changes in TOS, TAS, PON1, and arylesterase activities were noticed in Group II.
Neg (no) Regulation (changes) of arylesterase
5) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.26 Pain Relevance 0
Mean and SD values of PON1 and arylesterase activities, as well as TAS and TOS levels are presented in Table 2.
Regulation (values) of arylesterase
6) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.16 Pain Relevance 0.05
In contrast, no significant changes in TOS, TAS, PON1, and arylesterase activities were observed in Group II.
Neg (no) Regulation (changes) of arylesterase
7) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.64 Pain Relevance 0
Herein, we investigated the effects of pneumoperitoneum on oxidative stress markers, including paraoxonase, arylesterase, total oxidant status, and total antioxidant status, during laparoscopic cholecystectomy.


Spec (investigated) Regulation (effects) of arylesterase associated with stress and pneumoperitoneum
8) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2845769 Disease Relevance 0.56 Pain Relevance 0.08

General Comments

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