INT263822

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 11.00
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (LOX) extracellular space (LOX) oxidoreductase activity (LOX)
extracellular region (LOX) nucleus (LOX)
Anatomy Link Frequency
blood vessel 3
epithelium 1
LOX (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 96.68 Very High Very High Very High
antagonist 2 78.40 Quite High
cINOD 79 63.60 Quite High
licofelone 7 24.92 Low Low
Inflammation 13 13.48 Low Low
Osteoarthritis 1 12.64 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 165 100.00 Very High Very High Very High
Renal Cancer 118 100.00 Very High Very High Very High
Prostatic Intraepithelial Neoplasia 42 100.00 Very High Very High Very High
Breast Cancer 112 99.24 Very High Very High Very High
Benign Prostatic Hypertrophy 42 99.12 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 98.64 Very High Very High Very High
Hepatocellular Cancer 15 98.36 Very High Very High Very High
Colon Cancer 28 97.16 Very High Very High Very High
Cancer 148 97.12 Very High Very High Very High
Aggression 18 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting overexpression of inducible enzymes, 5-LOX and COX-2 enzymes, as a
Positive_regulation (overexpression) of Gene_expression (overexpression) of LOX
1) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.41 Pain Relevance 0.04
We have shown that 5- and 12-LOX expressions in RCC tissues were stronger than those in NK tissues by immunohistochemical staining (50 RCC and 10 NK tissues) and RT-PCR (Figure 2).
Positive_regulation (stronger) of Gene_expression (expressions) of LOX associated with renal cancer
2) Confidence 0.27 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.27 Pain Relevance 0.25
In conclusion, 5-LOX expression is strong in RCC.
Positive_regulation (strong) of Gene_expression (expression) of LOX associated with renal cancer
3) Confidence 0.27 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.42 Pain Relevance 0.09
We classified 3 categories (epithelium, blood vessel, stromal tissue) in NP, BPH, PIN, and PC tissues, and examined the intensity of 5- and 12-LOX expressions. 5- and 12-LOX expressions were more intensive and extensive in all categories of PC and PIN tissues as compared with NP and BPH tissues (Table 2).
Positive_regulation (intensive) of Gene_expression (expressions) of LOX in blood vessel associated with prostatic intraepithelial neoplasia, benign prostatic hypertrophy and reprotox - general 1
4) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.95 Pain Relevance 0.19
We have shown that 5- and 12-LOX expressions in PC and PIN tissue are stronger than those in NP and BPH tissues by immunohistochemical staining (174 PC, 20 PIN, 20 BPH, and 20 NP tissues) and RT-PCR.
Positive_regulation (stronger) of Gene_expression (expressions) of LOX associated with benign prostatic hypertrophy, prostatic intraepithelial neoplasia and reprotox - general 1
5) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.94 Pain Relevance 0.31
However, overexpression of ACSL4 resulted in slight by not statistically significant increase in 5-LOX expression (data not shown).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of LOX
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.47 Pain Relevance 0
In addition, increased expression of cyclooxygenase-2 (COX-2) and of 5-lipooxygenase (5-LOX) has been reported in aggressive metastatic breast cancer cells [22], [23].
Positive_regulation (increased) of Gene_expression (expression) of LOX associated with advanced or metastatic breast cancer
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 1.11 Pain Relevance 0
The formation of 5-, 12-, and 15-LOX products was significantly increased in cells overexpressing ACSL4 than in cells treated with tetracycline (Fig. 6C).
Positive_regulation (increased) of Gene_expression (products) of LOX
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.48 Pain Relevance 0
We classified 3 categories (epithelium, blood vessel, stromal tissue) in NP, BPH, PIN, and PC tissues, and examined the intensity of 5- and 12-LOX expressions. 5- and 12-LOX expressions were more intensive and extensive in all categories of PC and PIN tissues as compared with NP and BPH tissues (Table 2).
Positive_regulation (intensive) of in epithelium Gene_expression (expressions) of LOX in blood vessel associated with prostatic intraepithelial neoplasia, benign prostatic hypertrophy and reprotox - general 1
9) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.95 Pain Relevance 0.19

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