INT263824

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.28
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (LOX) extracellular space (LOX) oxidoreductase activity (LOX)
extracellular region (LOX) nucleus (LOX)
LOX (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 71.12 Quite High
COX-2 inhibitor 25 70.36 Quite High
licofelone 9 50.80 Quite High
Osteoarthritis 2 41.68 Quite Low
Inflammation 25 39.84 Quite Low
cINOD 34 37.28 Quite Low
cytokine 15 18.24 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 54 99.84 Very High Very High Very High
Cancer 72 98.40 Very High Very High Very High
Apoptosis 57 98.32 Very High Very High Very High
Lung Cancer 42 97.68 Very High Very High Very High
Birth Weight 23 96.00 Very High Very High Very High
Necrosis 6 92.36 High High
Benign Prostatic Hypertrophy 14 92.00 High High
Malignant Neoplastic Disease 6 91.32 High High
Prostatic Intraepithelial Neoplasia 14 90.56 High High
Renal Cancer 59 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
designing a single compound that might target both LOX and COX pathways is a strategy
Spec (might) Positive_regulation (target) of LOX
1) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.66 Pain Relevance 0.05
An interesting example of the double effect, inhibition of 5-LOX and activation
Positive_regulation (activation) of LOX
2) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.35 Pain Relevance 0.04
Consistent with our findings, Kelavkar and colleagues (2004) reported 15-LOX-1 is expressed in NP and increased in PC, especially high-grade PC.
Positive_regulation (increased) of LOX associated with reprotox - general 1
3) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.90 Pain Relevance 0.15
Faronato and colleagues (2007) reported increased 5-LOX protein and mRNA correlated with large tumor size (>4 cm) and age of patients.
Positive_regulation (increased) of LOX associated with cancer
4) Confidence 0.27 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.39 Pain Relevance 0.03
Haemoglobin was inversely related to the level of COX-1, COX-2 and IL-10 but increased with 15-LOX (SP R = -0.58, -0.57, -0.51, 0.48 respectively, p < 0.001 for each) (Figure 2A).
Positive_regulation (increased) of LOX
5) Confidence 0.08 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 0.97 Pain Relevance 0

General Comments

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