INT263849

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.19
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 89.04 High High
Glutamate receptor 4 87.12 High High
Inflammation 48 54.60 Quite High
Spinal cord 8 28.88 Quite Low
dopaminergic neurodegeneration 1 27.24 Quite Low
Neuritis 4 27.20 Quite Low
Substantia nigra 17 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Dopamine 11 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 91 100.00 Very High Very High Very High
Targeted Disruption 22 99.08 Very High Very High Very High
Neurodegenerative Disease 6 97.64 Very High Very High Very High
Stress 19 96.08 Very High Very High Very High
Immunization 48 94.48 High High
Cleidocranial Dysplasia 25 92.96 High High
Disease 76 91.20 High High
Parkinson's Disease 89 88.00 High High
Influenza Virus Infection 120 86.24 High High
Neuromyelitis Optica 124 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hydrogen-containing water and its H2 content
H2 Binding (content) of
1) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.97 Pain Relevance 0
4.3, h2?
h2 Binding (4.3) of
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2962628 Disease Relevance 0.43 Pain Relevance 0
In the present study, we found that MAb S139/1 bound to all the strains of H1, H2, H3, H5, H9, and H13 subtypes tested by ELISA, whereas it showed neutralization and HI activities to some particular strains tested.
H2 Binding (bound) of associated with sprains and strains
3) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.37 Pain Relevance 0
Relative neutralizing activities of MAb139/1 were also correlated with its reactivity to these viruses in the HI test and ELISA (i.e., MAb S139/1 neutralized Aichi (H3), WSN (H1), Adachi (H2), and Maryland (H13) in order of increasing activity).
H2 Binding (neutralized) of
4) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.83 Pain Relevance 0
Consistent with its reactivity profile in HI tests and ELISA, MAb S139/1 neutralized infectivity of WSN (H1), Adachi (H2), Aichi (H3), and Maryland (H13) strains.
H2 Binding (infectivity) of associated with sprains and strains
5) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.98 Pain Relevance 0
Using triple transgenic mice, we are able to simulate the functional interaction between human CD4 and human MHC-II molecules.
MHC-II Binding (interaction) of associated with targeted disruption
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.57 Pain Relevance 0.04
In contrast to B cells and their secreted antibodies, which frequently recognize conformational determinants, Ag-specific CD4+ T cells recognize specific Ag determinants in association with MHC II molecules expressed on the cell surface of Ag presenting cells (APCs) [16].
MHC II Binding (association) of in T cells
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.56 Pain Relevance 0.05
Although peptide fragments can bind cell surface MHC molecules directly and elicit T cell immune responses, presentation of native Ag by APCs to CD4+ T cells in vivo usually requires processing, which involves proteolytic degradation of protein within APCs and association of peptide cleavage products with MHC II molecules [19], [20].
MHC II Binding (association) of in T cell
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.35 Pain Relevance 0
Although intriguing, T cell recognition of this same region of AQP4 is probably coincidental, since determinants recognized by CD4+ T cells are generally created through processing and association with MHC II molecules [16].
MHC II Binding (association) of in T cells
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0 Pain Relevance 0.04
In general, MHC II-restricted CD4+ T cells recognize 9-13 amino acid peptides [16], [20].
MHC II Binding (recognize) of in T cells
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox