INT263932

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.43
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
occipital region 1
PROCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 98.40 Very High Very High Very High
antagonist 5 96.16 Very High Very High Very High
cytokine 35 82.72 Quite High
Electroencephalography 31 76.40 Quite High
Inflammatory response 9 54.32 Quite High
ischemia 7 50.00 Quite Low
headache 3 32.40 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombophilia 40 99.96 Very High Very High Very High
INFLAMMATION 46 98.40 Very High Very High Very High
Congenital Anomalies 5 97.52 Very High Very High Very High
Frailty 2 93.76 High High
Pregnancy Complications 24 91.36 High High
Coagulation Disorder 2 88.76 High High
Stress 19 87.92 High High
Spontaneous Abortion 9 87.68 High High
Eclampsia 34 84.64 Quite High
Endotoxemia 22 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Determination of the activated protein-C (APC-R) ratio was achieved by the measurement of two different activated partial thromboplastin time (APTT).
Positive_regulation (activated) of APC-R
1) Confidence 0.67 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694013 Disease Relevance 0.09 Pain Relevance 0
The search was updated in February 2010.We identified the following relevant MeSH and free terms for the exposures and outcomes by literature review and by recommendations from experts in the field (MAR, MC): Thrombophilia, activated protein C resistance (APCR), FVL, and PGM (PGM, PGV, G202110A, G1691A) for the exposure.
Positive_regulation (activated) of APCR associated with thrombophilia
2) Confidence 0.67 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.84 Pain Relevance 0
The released PUFAHP can then be a substrate for peroxisomal beta-oxidation and activate nuclear receptors such as peroxisome proliferators activated receptor (PPAR) alpha, a transcription factor for a series of enzymes involved in fatty acid metabolism including peroxisomal beta oxidation [14].
Positive_regulation (activate) of activated receptor
3) Confidence 0.03 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.31 Pain Relevance 0
To demonstrate that the increase in luciferase activity was really dependent upon the re-activated receptor, we exposed the transfected cells to the PPAR?
Positive_regulation (dependent) of re-activated receptor
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.11 Pain Relevance 0.05
To demonstrate that the increase in luciferase activity was really dependent upon the re-activated receptor, we exposed the transfected cells to the PPAR?
Positive_regulation (increase) of re-activated receptor
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.12 Pain Relevance 0.05
LPS induced a significant increase of the peak frequency and absolute band power of alpha and beta activity in the occipital region, P4O2 and P3O1 (all P < 0.0001).
Positive_regulation (increase) of P4O2 in occipital region
6) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2911704 Disease Relevance 0.45 Pain Relevance 0.19
The mechanisms of action of SepA, a serine protease, remain unknown although studies have suggested that proteases via their activation of protease activated receptor are involved in the pathogenesis of GI inflammation, in part by increasing paracellular permeability [18]–[20].
Positive_regulation (activation) of activated receptor associated with inflammation
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2653194 Disease Relevance 0.51 Pain Relevance 0.18

General Comments

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