INT2640

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2011
Negated 13
Speculated 6
Reported most in Abstract
Documents 424
Total Number 436
Disease Relevance 120.72
Pain Relevance 155.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
plasma 32
pituitary 30
arcuate nucleus 19
melanocyte 13
brain 10
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 987 100.00 Very High Very High Very High
Central nervous system 973 100.00 Very High Very High Very High
agonist 906 100.00 Very High Very High Very High
Opioid 488 100.00 Very High Very High Very High
Enkephalin 367 100.00 Very High Very High Very High
Morphine 362 100.00 Very High Very High Very High
Neuropeptide 222 100.00 Very High Very High Very High
Pain 211 100.00 Very High Very High Very High
Neurotransmitter 173 100.00 Very High Very High Very High
opioid receptor 163 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 579 100.00 Very High Very High Very High
Pain 175 100.00 Very High Very High Very High
Headache 17 100.00 Very High Very High Very High
Obesity 3430 99.98 Very High Very High Very High
Cancer 876 99.96 Very High Very High Very High
Pituitary Cancer 833 99.96 Very High Very High Very High
Carcinoma 260 99.96 Very High Very High Very High
Adenoma 197 99.96 Very High Very High Very High
Pheochromocytoma 52 99.96 Very High Very High Very High
Metastasis 467 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies focused on changes in POMC gene expression (mRNA quantitation) and post-translational processing.
Gene_expression (expression) of POMC gene
1) Confidence 0.78 Published 1988 Journal Alcohol Section Abstract Doc Link 2969250 Disease Relevance 0.16 Pain Relevance 0.32
This study investigated whether elimination of beta-endorphin (BE) synthesis via site-directed mutagenesis in embryonic stem cells would alter alcohol intake in mice.
Gene_expression (synthesis) of beta-endorphin in embryonic stem cells associated with alcohol
2) Confidence 0.78 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11166066 Disease Relevance 0 Pain Relevance 0.38
These results imply that the hypothalamic POMC gene and beta-endorphin expression may play an important role in the development of an acute physical dependency of morphine.
Gene_expression (expression) of POMC gene associated with morphine
3) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.84
Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration.
Gene_expression (expression) of POMC gene associated with narcan and morphine
4) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.95
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Gene_expression (expression) of beta-endorphin associated with morphine
5) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Gene_expression (expression) of beta-endorphin associated with morphine
6) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
These results imply that the hypothalamic POMC gene and beta-endorphin expression may play an important role in the development of an acute physical dependency of morphine.
Gene_expression (expression) of beta-endorphin associated with morphine
7) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.83
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Gene_expression (expression) of POMC gene associated with morphine
8) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and beta-endorphin.
Gene_expression (expression) of beta-endorphin associated with morphine
9) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.48
In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration.
Gene_expression (expression) of POMC gene associated with gabaergic and morphine
10) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.76
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Gene_expression (expression) of POMC gene associated with morphine
11) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.
Gene_expression (expression) of beta-endorphin associated with withdrawal and morphine
12) Confidence 0.78 Published 2009 Journal Brain Res. Bull. Section Title Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.57
Because the opioid peptide beta-endorphin is co-synthesized and released with melanocortins from proopiomelanocortin (POMC) neuronal terminals, we examined the physiological role of beta-endorphin in feeding and energy homeostasis using a strain of mutant mice with a selective deficiency of beta-endorphin.
Gene_expression (synthesized) of beta-endorphin in neuronal associated with sprains and strains and opioid
13) Confidence 0.78 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851316 Disease Relevance 0.24 Pain Relevance 0.19
The pro-opiomelanocortin (POMC) gene is expressed in a subset of hypothalamic and hindbrain neurons and in pituitary melanotrophs and corticotrophs.
Gene_expression (expressed) of pro-opiomelanocortin in neurons
14) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9712635 Disease Relevance 0.14 Pain Relevance 0.09
In situ hybridization studies showed an accurate cell-specific pattern of expression of POMC27* in the arcuate nucleus and the pituitary.
Gene_expression (expression) of POMC27 in arcuate nucleus
15) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9712635 Disease Relevance 0.25 Pain Relevance 0.07
RNase protection assays revealed that POMC27* expression mimicked that of POMC in different areas of the CNS and most peripheral organs with no detectable ectopic expression.
Gene_expression (expression) of POMC27
16) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9712635 Disease Relevance 0.22 Pain Relevance 0.05
POMC gene expression in the CNS is believed to be controlled by distinct cis-acting regulatory sequences.
Gene_expression (expression) of POMC gene
17) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9712635 Disease Relevance 0.16 Pain Relevance 0.10
Thirty fragments of beta-endorphin have been synthesized and their ability to inhibit the [3H]immunorphin specific binding to macrophages was studied.
Gene_expression (synthesized) of beta-endorphin in macrophages
18) Confidence 0.78 Published 2008 Journal J. Pept. Sci. Section Abstract Doc Link 18618430 Disease Relevance 0 Pain Relevance 0.19
Thirty fragments of beta-endorphin were synthesized, and their ability to inhibit the specific binding of [3H]immunorphin to macrophages was studied.
Gene_expression (synthesized) of beta-endorphin in macrophages
19) Confidence 0.78 Published 2008 Journal Bioorg. Khim. Section Abstract Doc Link 18365735 Disease Relevance 0 Pain Relevance 0.27
Our results show a significant decrease in the POMC gene expression by the S(-)-enantiomer of SAL.
Gene_expression (expression) of POMC gene
20) Confidence 0.78 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32

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