INT264027

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 2.67
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
frontal cortex 12
hippocampus 4
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 72 100.00 Very High Very High Very High
gABA 97 99.84 Very High Very High Very High
Hippocampus 43 96.48 Very High Very High Very High
Calcium channel 24 74.16 Quite High
carbamazepine 66 64.60 Quite High
Lamotrigine 32 63.84 Quite High
sodium channel 32 60.76 Quite High
repetitive firing 8 58.96 Quite High
Spinal cord 9 56.04 Quite High
Serotonin 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 95.84 Very High Very High Very High
Epilepsy 248 81.84 Quite High
Convulsion 584 79.12 Quite High
Absence Epilepsy 72 77.60 Quite High
Partial Seizures 280 49.08 Quite Low
Dentatorubro-pallidoluysian Atrophy 152 5.00 Very Low Very Low Very Low
Infantile Spasms 144 5.00 Very Low Very Low Very Low
Depression 94 5.00 Very Low Very Low Very Low
Disease 79 5.00 Very Low Very Low Very Low
Syndrome 69 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure with milnacipran, however, caused time- and concentration-dependent increases in NE uptake and NE transporter density with no increase in NE transporter mRNA.
Positive_regulation (caused) of Positive_regulation (increases) of transporter
1) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0 Pain Relevance 0
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of Positive_regulation (up) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
2) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of Positive_regulation (-) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
3) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (up) of Positive_regulation (-) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
4) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of Positive_regulation (up) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
5) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of in hippocampus Positive_regulation (-) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
6) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of in hippocampus Positive_regulation (up) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
7) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (up) of in hippocampus Positive_regulation (-) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
8) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of in hippocampus Positive_regulation (up) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
9) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.33 Pain Relevance 0.91

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