INT264065

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.14

cytoplasm (Lrtomt)

Lrtomt (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 26 98.80 depression 5 8.60 Pain 4 7.08 deep brain stimulation 5 5.00 Bioavailability 3 5.00 anesthesia 2 5.00 fibrosis 2 5.00 tolerance 2 5.00 Dopamine 2 5.00 ergotamine 2 5.00

Disease Link Frequency Relevance Heat Toxicity 4 82.32 Phobia 2 77.04 Disease 49 73.04 Dyskinesias 32 48.04 Parkinson's Disease 11 24.72 Hallucination 10 17.52 Cognitive Disorder 6 14.52 Depression 7 8.60 Anxiety Disorder 4 8.00 Pain 4 7.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been demonstrated that different strategies for smoothing out the levodopa stimulation pattern by the early use of agonists, as mentioned above as well as with inhibitors of levodopa degradation (catechol-O-methyl transferase or COMT inhibitors), all delay the development of these complications (Olanow et al 2001; Stocchi and Olanow 2004).

Protein_catabolism (degradation) of catechol-O-methyl transferase associated with agonist

1) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654791 Disease Relevance 0.63 Pain Relevance 0.14

General Comments

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