INT264100

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.45
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNT1) nucleolus (CCNT1) nucleus (CCNT1)
cell cycle (CCNT1) DNA binding (CCNT1) cell division (CCNT1)
Anatomy Link Frequency
monocytes 4
macrophages 2
CCNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 12 81.64 Quite High
cytokine 73 76.32 Quite High
Glutamate 7 75.92 Quite High
Inflammation 25 73.12 Quite High
nMDA receptor 3 67.52 Quite High
agonist 2 64.96 Quite High
Action potential 1 58.48 Quite High
Dopamine 1 56.32 Quite High
antidepressant 5 51.96 Quite High
Substantia nigra 1 50.48 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 14 94.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 847 94.08 High High
Neuroblastoma 1 87.08 High High
Immunodeficiency 24 80.00 Quite High
Infection 66 77.32 Quite High
Toxicity 8 76.28 Quite High
Injury 8 75.36 Quite High
INFLAMMATION 31 73.12 Quite High
Opportunistic Infections 6 68.56 Quite High
Disease 221 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, it has been observed that cyclin T1 expression in monocytes is controlled by differentiation.
Gene_expression (expression) of cyclin T1 in monocytes
1) Confidence 0.34 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.53 Pain Relevance 0
The presence of Tat has little effect on transcription in monocytes, as cyclin T1 expression is undetectable and other factors required for Tat activation are absent [54].
Gene_expression (expression) of cyclin T1 in monocytes
2) Confidence 0.34 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.41 Pain Relevance 0.11
Specifically, it has been observed that cyclin T1 expression in monocytes is controlled by differentiation.
Gene_expression (expression) of cyclin T1 in monocytes
3) Confidence 0.34 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.73 Pain Relevance 0.15
Differentiation into macrophages increases Cyclin T1 expression and results in strong Tat activity [54].
Gene_expression (expression) of Cyclin T1 in macrophages
4) Confidence 0.27 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.15 Pain Relevance 0
Tat activity has been shown to be limited in monocytes due to the lack of sufficient levels of cyclin T1, a component of P-TEFb [54].
Gene_expression (levels) of cyclin T1 in monocytes
5) Confidence 0.27 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.16 Pain Relevance 0
Differentiation into macrophages increases Cyclin T1 expression and results in strong Tat activity [54].
Gene_expression (expression) of Cyclin T1 in macrophages
6) Confidence 0.27 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.14 Pain Relevance 0
Donepezil reduces the number of cells in the S-G2/M phases of the cell cycle, increases the G0/G1 population, and reduces the expression of two cyclins of the G1/S and G2/M transitions, cyclin E and cyclin B, in parallel with an increase in the expression of the cell cycle inhibitor p21 (Sortino et al 2004).
Gene_expression (expression) of cyclin B
7) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.33 Pain Relevance 0.24

General Comments

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