INT264107

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1, CYP2D6) oxidoreductase activity (Cyp2e1, CYP2D6) endoplasmic reticulum (Cyp2e1, CYP2D6)
small molecule metabolic process (CYP2D6) enzyme binding (Cyp2e1)
Cyp2e1 (Mus musculus)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 95.56 Very High Very High Very High
Catechol-O-methyltransferase 2 74.96 Quite High
monoamine 1 32.28 Quite Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 167 50.00 Quite Low
Adverse Drug Reaction 13 8.24 Low Low
Hepatotoxicity 2 6.68 Low Low
Cognitive Disorder 55 5.00 Very Low Very Low Very Low
Dementia 34 5.00 Very Low Very Low Very Low
Vascular Dementia 16 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 14 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The microsomal, membrane-associated, P450 isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 are responsible for the oxidative metabolism of more than 90% of marketed drugs; and CYP3A4 metabolizes more drug molecules than all other isoforms together.
CYP2E1 Regulation (responsible) of CYP2D6
1) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.09

General Comments

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