INT264115

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.73
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ripk4) kinase activity (Ripk4) cytoplasm (Ripk4)
Anatomy Link Frequency
microglial cells 1
Ripk4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 87.12 High High
Multiple sclerosis 2 67.16 Quite High
Spinal cord 1 66.08 Quite High
ischemia 2 65.56 Quite High
Inflammation 13 60.80 Quite High
Neuritis 2 46.52 Quite Low
adenocard 11 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 9 100.00 Very High Very High Very High
Synovial Sarcoma 70 99.84 Very High Very High Very High
Sarcoma 14 95.84 Very High Very High Very High
Apoptosis 15 94.80 High High
Cancer 15 94.56 High High
Disease 40 93.44 High High
Alzheimer's Dementia 5 88.32 High High
Malignant Neoplastic Disease 4 84.32 Quite High
Lung Cancer 3 73.44 Quite High
Epilepsy 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activator RIPK4 is highly upregulated in synovial sarcoma, and the data
Positive_regulation (upregulated) of RIPK4 associated with synovial sarcoma
1) Confidence 0.29 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.35 Pain Relevance 0
Expression profiling studies by us and others have shown that RIPK4, an activator of NF-?
Positive_regulation (activator) of RIPK4
2) Confidence 0.21 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 0.74 Pain Relevance 0
Staining with a monoclonal antibody specific for activated microglial cells revealed a marked increase in these cells in the rims of senile plaques (Dik et al 2005).
Positive_regulation (increase) of Dik in microglial cells associated with amyloid plaque
3) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 1.64 Pain Relevance 0.17

General Comments

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