INT264130

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.13
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINA3) nucleus (SERPINA3) intracellular (SERPINA3)
DNA binding (SERPINA3)
Anatomy Link Frequency
plaque 2
SERPINA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 100.00 Very High Very High Very High
cytokine 38 98.48 Very High Very High Very High
Multiple sclerosis 3 77.00 Quite High
Spinal cord 1 75.92 Quite High
ischemia 2 75.40 Quite High
Neuritis 1 62.32 Quite High
fibrosis 2 5.52 Low Low
adenocard 11 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 35 100.00 Very High Very High Very High
INFLAMMATION 19 100.00 Very High Very High Very High
Disease 92 99.84 Very High Very High Very High
Necrosis 1 99.58 Very High Very High Very High
Cancer 4 99.40 Very High Very High Very High
Amyloid Plaque 14 96.16 Very High Very High Very High
Apoptosis 4 84.16 Quite High
Epilepsy 1 78.88 Quite High
Creutzfeldt Jakob Disease 1 77.64 Quite High
Multiple Sclerosis 4 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among them, complement proteins, from the initial component C1q through the terminal cytotoxic C5b-C9, the complement receptors CR3 and CR4, and complement inhibitors, cytokines and interleukins (TNF-alpha, IL-1, IL-2, IL-6), and acute phase reactants (alpha1-antichymotrypsin and alpha2-macroglobulin) were exclusively localized in AD plaques.
Localization (localized) of alpha1-antichymotrypsin in plaques associated with disease and cytokine
1) Confidence 0.78 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 1.68 Pain Relevance 0.20
Interleukin 1 alpha, interleukin 6, and tumour necrosis factor are all been localised within plaques, and acute phase proteins involved in inflammation, such as amyloid P, alpha-1 antichymotrypsin, and C-reactive protein are also plaque components while immunoglobulin G is located in the plaque corona [14, 40–42].
Localization (localised) of alpha-1 antichymotrypsin in plaque associated with necrosis, inflammation, cancer and alzheimer's dementia
2) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 1.45 Pain Relevance 0.19

General Comments

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