INT26415

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Context Info
Confidence 0.01
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PKIA) cytoplasm (PKIA)
Anatomy Link Frequency
neurons 2
locus coeruleus 2
PKIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Locus ceruleus 22 99.68 Very High Very High Very High
Morphine 32 99.62 Very High Very High Very High
tolerance 4 95.16 Very High Very High Very High
addiction 4 94.48 High High
Raphe 2 65.20 Quite High
opiate 4 55.44 Quite High
antagonist 2 48.08 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of cAMP-dependent protein phosphorylation by acute and chronic morphine was studied in the rat locus coeruleus (LC), a brain region that appears to play an important role in mediating morphine action in animals, including humans.
Regulation (Regulation) of Phosphorylation (phosphorylation) of cAMP-dependent protein in locus coeruleus associated with locus ceruleus and morphine
1) Confidence 0.01 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2556507 Disease Relevance 0 Pain Relevance 0.73
Taken together, the results of this study indicate that chronic morphine produces specific alterations in cAMP-dependent protein phosphorylation in the LC and raise the possibility that regulation of these specific phosphoproteins contributes to the development of tolerance and/or dependence in these neurons.
Regulation (alterations) of Phosphorylation (phosphorylation) of cAMP-dependent protein in neurons associated with addiction, locus ceruleus, tolerance and morphine
2) Confidence 0.01 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2556507 Disease Relevance 0.06 Pain Relevance 1.32

General Comments

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