INT264171

Context Info Confidence 0.49 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.74 Pain Relevance 0.94

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4) enzyme binding (CD4)

Anatomy Link Frequency immune cells 2 regulatory T cells 2 T cells 2 CD4 (Homo sapiens)

Pain Link Frequency Relevance Heat 5HT 23 99.98 cytokine 11 99.44 Inflammation 51 99.38 Serotonin 4 92.60 monoamine 1 75.96 Endocannabinoid 4 74.56 Pain 5 74.32 Multiple sclerosis 83 72.48 sSRI 5 71.84 qutenza 1 36.32

Disease Link Frequency Relevance Heat INFLAMMATION 54 99.38 Sarcoidosis 17 98.92 Cold Sores 82 98.40 Lymphadenopathy 6 98.36 Thyroid Disease 39 98.26 Disease 141 91.08 Autoimmune Disease 25 90.24 Acquired Immune Deficiency Syndrome Or Hiv Infection 101 85.80 Granuloma 3 85.04 Skin Cancer 44 83.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bronchoalveolar lavage (BAL) showed an increase in total cell count and an elevated CD4/CD8 ratio compatible with sarcoidosis, and absence of neoplastic cells or infectious agents.

Positive_regulation (increase) of Positive_regulation (elevated) of CD4 associated with sarcoidosis

1) Confidence 0.49 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2924355 Disease Relevance 1.16 Pain Relevance 0.07

However, it is possible that the CD4+ T cell values at the lesion-visits may in fact represent the “elevated” values due to increased activation of CD4+ and other immune cells in response to HSV-2 reactivation which may exacerbate CD4+ T cell loss.

Positive_regulation (increased) of Positive_regulation (activation) of CD4 in immune cells associated with cold sores

2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848613 Disease Relevance 1.26 Pain Relevance 0

Another possible caveat of the method used in this study is that surface CD25 and intracellular Foxp3 expressions are not strictly specific of Treg cells in humans, as both these markers are upregulated after activation in a significant proportion of CD4+ non-regulatory T cells.

Neg (not) Positive_regulation (upregulated) of Positive_regulation (proportion) of CD4 in regulatory T cells

3) Confidence 0.26 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936304 Disease Relevance 0.83 Pain Relevance 0

Of direct relevance to inflammation is the demonstration that 5HT enhanced monocyte stimulation of CD4+ T cells and cytokine production following LPS exposure [261].

Positive_regulation (enhanced) of Positive_regulation (stimulation) of CD4 in T cells associated with inflammation, 5ht and cytokine

4) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.35 Pain Relevance 0.86

AITD patients were more likely than controls to be severely compromised at baseline and to experience greater CD4 increments following HAART.

Positive_regulation (experience) of Positive_regulation (increments) of CD4 associated with thyroid disease

5) Confidence 0.09 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.15 Pain Relevance 0

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