INT264177

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.59
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Ctla4) plasma membrane (Ctla4)
Anatomy Link Frequency
eosinophils 2
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 74 78.52 Quite High
Inflammation 29 78.16 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hookworm Infection 35 98.36 Very High Very High Very High
Mycobacterial Infection 140 98.08 Very High Very High Very High
Infection 136 95.96 Very High Very High Very High
INFLAMMATION 32 92.28 High High
Toxicity 2 91.20 High High
Autoimmune Disease 4 90.88 High High
Hypersensitivity 4 89.48 High High
Schistosomiasis 2 67.60 Quite High
Worm Infection 21 65.72 Quite High
Disease 9 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, an increased expression of CTLA-4/CD152 was observed in eosinophils from infected donors.
Positive_regulation (increased) of Gene_expression (expression) of CD152 in eosinophils
1) Confidence 0.49 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.47 Pain Relevance 0.03
and Th17 (IL-23/IL-17) responses related to increased expression of CTLA-4 and PD-1 [21].
Positive_regulation (increased) of Gene_expression (expression) of CTLA-4
2) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.25 Pain Relevance 0.08
and Th17 (IL-23/IL-17) responses related to increased CTLA-4 and PD-1 expression (manuscript in press).
Positive_regulation (increased) of Gene_expression (expression) of CTLA-4
3) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.87 Pain Relevance 0.06

General Comments

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