INT264191

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1A) plasma membrane (CD1A)
Anatomy Link Frequency
CD86 2
monocytes 2
CD1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 74.88 Quite High
cytokine 40 65.20 Quite High
antagonist 1 22.08 Low Low
chemokine 9 11.28 Low Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hookworm Infection 35 99.46 Very High Very High Very High
Infection 28 75.00 Quite High
INFLAMMATION 18 74.88 Quite High
Worm Infection 13 74.40 Quite High
Stress 3 67.68 Quite High
Apoptosis 7 45.48 Quite Low
Obesity 23 5.00 Very Low Very Low Very Low
Helminth Infection 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Positive_regulation (presented) of Gene_expression (expression) of CD1a in CD86 associated with hookworm infection
1) Confidence 0.26 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.57 Pain Relevance 0
Similar to leptin effect on monocytes,it may increase the survival of dendritic cells, and it may also increase the expression of surface molecules, such as CD1a, CD80, CD83, or CD86.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of CD1a in monocytes
2) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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