INT264192

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.06
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CTLA4) plasma membrane (CTLA4)
Anatomy Link Frequency
T-cell 6
eosinophils 2
cytotoxic T lymphocyte 2
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 74 92.12 High High
Inflammation 47 91.72 High High
Pain 1 77.44 Quite High
adenocard 3 67.36 Quite High
ischemia 1 59.32 Quite High
agonist 5 39.96 Quite Low
abatacept 8 30.24 Quite Low
corticosteroid 42 25.52 Quite Low
Nerve growth factor 1 22.00 Low Low
tolerance 26 13.12 Low Low
Disease Link Frequency Relevance Heat
Cancer 53 98.64 Very High Very High Very High
Hookworm Infection 35 98.36 Very High Very High Very High
Necrosis 4 98.24 Very High Very High Very High
Infection 43 93.16 High High
Apoptosis 8 93.00 High High
INFLAMMATION 46 91.72 High High
Toxicity 12 91.20 High High
Autoimmune Disease 21 89.92 High High
Pain 1 77.44 Quite High
Reperfusion Injury 1 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD28 is constitutively expressed on T-cells, whereas CTLA-4 expression is rapidly upregulated following T-cell activation.
Positive_regulation (upregulated) of Gene_expression (expression) of CTLA-4 in T-cell
1) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Once activated, T cells express increased concentration of CTLA4.
Positive_regulation (increased) of Gene_expression (express) of CTLA4 in T cells
2) Confidence 0.39 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.07 Pain Relevance 0.06
Constitutive expression of CTLA-4 among CD4+ cells was restricted primarily to Tregs, suggesting that CTLA-4 expression by these cells is involved in their immune-suppressive function.
Positive_regulation (restricted) of Gene_expression (expression) of CTLA-4
3) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.22 Pain Relevance 0.21
Surprisingly, an increased expression of CTLA-4/CD152 was observed in eosinophils from infected donors.
Positive_regulation (increased) of Gene_expression (expression) of CTLA-4 in eosinophils
4) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.47 Pain Relevance 0.03
The homologue to CD28 is CTLA4 which is transiently expressed after T cell activation and negatively regulates T cell activation.
Positive_regulation (after) of Gene_expression (expressed) of CTLA4 in T cell
5) Confidence 0.16 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.36 Pain Relevance 0.15
Tregs express high levels of surface antigens such as CD25, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and glucocorticoid-induced tumor necrosis factor receptor (GITR) [23,24].
Positive_regulation (levels) of Gene_expression (express) of lymphocyte-associated antigen 4 in cytotoxic T lymphocyte associated with necrosis and cancer
6) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936304 Disease Relevance 0.95 Pain Relevance 0

General Comments

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