INT264200

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAX) plasma membrane (ITGAX)
Anatomy Link Frequency
monocytes 4
DCs 2
ITGAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 91.84 High High
cytokine 60 83.80 Quite High
chemokine 15 77.92 Quite High
Inflammatory stimuli 2 77.64 Quite High
antagonist 1 56.40 Quite High
corticosteroid 2 49.04 Quite Low
cINOD 3 47.28 Quite Low
Chronic pancreatitis 25 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 91.84 High High
Infection 55 88.00 High High
Hookworm Infection 70 79.52 Quite High
Cancer 84 75.20 Quite High
Obesity 24 72.56 Quite High
Congenital Anomalies 3 70.80 Quite High
Adenocarcinoma 96 66.16 Quite High
Parasitic Infection 4 61.08 Quite High
Helminth Infection 8 59.92 Quite High
Worm Infection 26 52.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immature monocyte-derived DCs can be subsequently matured with LPS, which determines the upregulation of their antigen-presenting and co-stimulatory molecules, together with higher expression of the integrin CD11c and lack of CD14.
Positive_regulation (lack) of Gene_expression (expression) of CD11c in DCs
1) Confidence 0.19 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.34 Pain Relevance 0.03
Differentiation of the monocytes into dendritic cells in non-infected individuals occurred as expected, with a relatively higher expression of CD11c and an absence lack of CD14 (Fig. 1A).
Positive_regulation (higher) of Gene_expression (expression) of CD11c in monocytes
2) Confidence 0.17 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.20 Pain Relevance 0.03
MDCs express high levels of CD11c, BDCA1, and BDCA3 and myeloid related surface molecules, whereas PDCs lack the myeloid markers including CD11c, but they express the IL-3 receptor (CD123) [13].
Positive_regulation (levels) of Gene_expression (express) of CD11c
3) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.39 Pain Relevance 0
Human leptin was found to stimulate proliferation and activation of human circulating monocytes in vitro, promoting the expression of activation markers: CD69, CD25, CD38, and CD71, in addition to increasing the expression of monocytes surface markers, such as HLA-DR, CD11b, and CD11c [24].
Positive_regulation (increasing) of Gene_expression (expression) of CD11c in monocytes
4) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.61 Pain Relevance 0.39

General Comments

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