INT264201

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAX) plasma membrane (ITGAX)
Anatomy Link Frequency
CD86 6
ITGAX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 83.24 Quite High
corticosteroid 3 82.04 Quite High
cytokine 48 51.40 Quite High
chemokine 18 26.84 Quite Low
Inflammation 15 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 12 99.12 Very High Very High Very High
Hookworm Infection 105 97.92 Very High Very High Very High
Infection 78 93.60 High High
Malaria 3 86.96 High High
INFLAMMATION 18 83.00 Quite High
Parasitic Infection 6 54.12 Quite High
Hyperplasia 6 52.32 Quite High
Worm Infection 39 45.16 Quite Low
Eosinophilia 6 26.24 Quite Low
Toxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this is indeed the case for matured DCs from non-infected donors, mDCs from Necator-infected individuals have a down-regulated expression of antigen-presenting, costimulatory (CD86) molecules, and CD11c, with the CD14 still present on the cell surface.
Negative_regulation (regulated) of Gene_expression (expression) of CD11c in CD86
1) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.41 Pain Relevance 0.12
However, here we demonstrated that hookworm ES products may be partially responsible for the alternative differentiation of DC, as observed by the reduction of CD11c and CD86 expression and increase of CD80 expression on the DC surface.
Negative_regulation (reduction) of Gene_expression (expression) of CD11c in CD86 associated with hookworm infection
2) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0.12
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Negative_regulation (decreased) of Gene_expression (expression) of CD11c in CD86 associated with helminth infection
3) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0

General Comments

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