INT264209

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.78
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a) cytoplasm (Sv2a)
Anatomy Link Frequency
synaptic vesicle 1
Igh-Lev (Mus musculus)
Sv2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 3 96.40 Very High Very High Very High
Calcium channel 3 94.04 High High
antiepileptic Drug 105 92.32 High High
Neurotransmitter 3 86.96 High High
carbamazepine 36 38.68 Quite Low
Gabapentin 18 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
Lamotrigine 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 3 88.92 High High
Partial Seizures 96 88.56 High High
Convulsion 276 82.56 Quite High
Generalized Epilepsy 24 80.92 Quite High
Epilepsy 132 77.84 Quite High
Juvenile Myoclonic Epilepsy 9 65.12 Quite High
Intellectual Impairment 6 40.04 Quite Low
Cognitive Disorder 84 31.52 Quite Low
Neurological Disease 6 30.24 Quite Low
Absence Epilepsy 6 18.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LEV is a novel AED that binds to SV2A proteins and acts through a mechanism that is distinct from any other currently available AED.
LEV Binding (binds) of SV2A
1) Confidence 0.17 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655081 Disease Relevance 0.49 Pain Relevance 0
LEV binds to a unique binding site in the brain, the synaptic vesicle protein SV2A.
LEV Binding (binds) of SV2A in synaptic vesicle
2) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655081 Disease Relevance 0.68 Pain Relevance 0.21
Whether LEV’s binding at SV2A proteins mediates these mechanisms is unknown (Lynch et al 2004).
LEV Spec (Whether) Binding (binding) of SV2A
3) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655081 Disease Relevance 0.60 Pain Relevance 0.17

General Comments

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