INT264241

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Cpz)
Cpz (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 91.72 High High
agonist 3 79.00 Quite High
aspirin 2 78.28 Quite High
Antihistamine 2 49.60 Quite Low
anesthesia 3 42.32 Quite Low
Hippocampus 8 6.72 Low Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hallucination 3 98.36 Very High Very High Very High
Psychosis 10 96.48 Very High Very High Very High
Mental Disorders 4 86.00 High High
Schizophrenia 42 55.96 Quite High
Surgical Shock 2 22.48 Low Low
Vomiting 2 7.20 Low Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two years later, in 1957, the importance of CPZ was recognized by the scientific community with the presentation of the American public health association’s prestigious Albert Lasker Award to the three key players in the clinical development of the drug: Henri Laborit, for using CPZ as a therapeutic agent first and recognizing its potential for psychiatry; Pierre Deniker, for his leading role in introducing CPZ into psychiatry and demonstrating its influence on the clinical course of psychosis; and Heinz Lehmann, for bringing the full practical significance of CPZ to the attention of the medical community (Ban 1994).
Positive_regulation (importance) of CPZ associated with psychosis
1) Confidence 0.60 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655089 Disease Relevance 0.08 Pain Relevance 0
Although the psychiatric establishment received CPZ incredulously, for psychiatrists working on the front line it was a miracle drug.
Positive_regulation (received) of CPZ
2) Confidence 0.43 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655089 Disease Relevance 0.28 Pain Relevance 0.13
In our recent study (Xu et al., 2009), a lower spontaneous alternation in the Y-maze was found in CPZ-treated mice starting from 14th day after CPZ treatment when DA levels increased in PFC and remained throughout the whole 6-weeks experimental period.
Positive_regulation (increased) of CPZ
3) Confidence 0.41 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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