INT26426

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.87
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5)
Anatomy Link Frequency
joint 1
trunk 1
microglia 1
C5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 99.74 Very High Very High Very High
Peripheral nerve injury 3 99.10 Very High Very High Very High
Spinal cord 4 98.30 Very High Very High Very High
rheumatoid arthritis 31 95.72 Very High Very High Very High
Inflammation 74 93.96 High High
Eae 2 93.84 High High
allodynia 1 92.76 High High
antagonist 2 91.84 High High
Pain 7 89.56 High High
Analgesic 1 83.52 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 99.74 Very High Very High Very High
Nervous System Injury 6 99.10 Very High Very High Very High
Injury 44 99.02 Very High Very High Very High
Candida Infection 137 98.84 Very High Very High Very High
Rheumatoid Arthritis 31 95.72 Very High Very High Very High
Rupture 9 95.60 Very High Very High Very High
INFLAMMATION 78 93.96 High High
Pain 6 89.56 High High
Hypersensitivity 31 86.08 High High
Disease 53 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can form immune complexes in the joint that could fix complement and release chemotactic factors, such as C5a, which in turn could attract neutrophils.
Localization (release) of C5a in joint
1) Confidence 0.78 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.81 Pain Relevance 0.34
Furthermore, CSBG has been shown to activate complement systems, including anaphylatoxin (C3a, C5a) release [44].
Localization (release) of anaphylatoxin associated with candida infection
2) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.20 Pain Relevance 0.14
We conclude that induction of the complement cascade in spinal cord microglia after peripheral nerve injury contributes to neuropathic pain through the release and action of the C5a anaphylatoxin peptide.
Localization (release) of C5a in microglia associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
3) Confidence 0.73 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17687047 Disease Relevance 1.13 Pain Relevance 1.04
AA-2379 inhibits formyl methionyl-leucyl-phenylalanine (fMLP)- and C5a-induced arachidonic acid release; their 50% inhibitory concentrations were 2.8 x 10(-5) and 3.8 x 10(-5) M, respectively.
Localization (release) of C5a
4) Confidence 0.68 Published 1989 Journal Agents Actions Section Abstract Doc Link 2556899 Disease Relevance 0.26 Pain Relevance 0.08
The clinical signs at evaluation of the patients indicated upper trunk injuries in case 1, which was confirmed at surgery as we found C5 and C6 avulsions.
Localization (found) of C5 in trunk associated with injury
5) Confidence 0.09 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2915998 Disease Relevance 0.47 Pain Relevance 0

General Comments

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