INT264277

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) transport (P2rx1) extracellular space (Car2)
lyase activity (Car2) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
urinary bladder 1
Appendix 1
Car2 (Mus musculus)
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 92.08 High High
imagery 21 80.72 Quite High
Action potential 45 5.84 Low Low
antagonist 36 5.00 Very Low Very Low Very Low
Neurotransmitter 15 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 48 5.00 Very Low Very Low Very Low
Aging 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Head Trauma 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that calcium-induced calcium release (CICR) augments the Ca2+ that enters the cell through the P2X1 receptor upon ATP binding, causing the delay between the onsets of the sEJP and the focal Ca2+ transient.
Ca2 Binding (receptor) of P2X1
1) Confidence 0.10 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0
This function arises from a simple model of Ca2+ influx through P2X1 receptors, with Ca2+ then cleared by a first-order process (see Appendix).


Ca2 Spec (cleared) Binding (receptors) of P2X1 in Appendix
2) Confidence 0.10 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.09
Binding of ATP to P2X1 receptors generates an influx of Na+ ions and Ca2+ ions (Isenberg et al. 1992; Evans et al. 1996), but it is unlikely that these movements are genuinely separated by 10 ms in SMCs of the mouse urinary bladder.
Ca2 Binding (Binding) of P2X1 in urinary bladder
3) Confidence 0.10 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox