INT26428

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Context Info
Confidence 0.00
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HK1) mitochondrion (HK1) small molecule metabolic process (HK1)
nucleolus (HK1) nucleus (HK1) carbohydrate metabolic process (HK1)
Anatomy Link Frequency
PMN 1
HK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 97.46 Very High Very High Very High
Analgesic 2 87.24 High High
Arthritis 100 86.00 High High
positron emission tomography 1 27.44 Quite Low
rheumatoid arthritis 50 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthus Reaction 2 98.48 Very High Very High Very High
Hypersensitivity 4 97.92 Very High Very High Very High
INFLAMMATION 10 97.46 Very High Very High Very High
Autoimmune Disease 9 93.40 High High
Arthritis 118 86.00 High High
Renal Disease 1 84.96 Quite High
Systemic Lupus Erythematosus 1 81.64 Quite High
Immune Complex Diseases 1 78.68 Quite High
Immunization 10 42.96 Quite Low
Targeted Disruption 16 30.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the inhibitory effect of AA-2379 on inflammation and allergic reactions such as the Arthus reaction is partly exerted by inhibiting PMN functions such as arachidonic acid and lysozomal enzyme release.
Localization (release) of lysozomal enzyme in PMN associated with inflammation, hypersensitivity and arthus reaction
1) Confidence 0.00 Published 1989 Journal Agents Actions Section Abstract Doc Link 2556899 Disease Relevance 0.40 Pain Relevance 0.05
AA-2379 at 10(-4) M inhibited lysozomal enzyme release.
Localization (release) of lysozomal enzyme
2) Confidence 0.00 Published 1989 Journal Agents Actions Section Abstract Doc Link 2556899 Disease Relevance 0.27 Pain Relevance 0.09
In addition to its function as a glycolytic enzyme, G6PI can be secreted and serves a variety of other physiological functions [99].
Localization (secreted) of glycolytic enzyme
3) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.77 Pain Relevance 0.12

General Comments

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