INT264300

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP27A1) peptidase activity (CTSK) extracellular space (CTSK)
small molecule metabolic process (CYP27A1) lysosome (CTSK) cytoplasm (CTSK)
CTSK (Homo sapiens)
CYP27A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 82.96 Quite High
Inflammation 18 56.44 Quite High
Infliximab 4 24.76 Low Low
cytokine 3 15.56 Low Low
methotrexate 2 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 8 99.24 Very High Very High Very High
Hypercalcemia 17 97.92 Very High Very High Very High
Rheumatoid Arthritis 27 82.96 Quite High
INFLAMMATION 20 56.44 Quite High
Disease 19 55.04 Quite High
Endometriosis (extended) 11 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Nicotine Addiction 4 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTX-1 is generated by cathepsin K, which is the key osteoclastic enzyme for systemic bone resorption.
cathepsin K Positive_regulation (generated) of CTX-1 associated with hypercalcemia and osteoporosis
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.69 Pain Relevance 0.07

General Comments

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