INT264313

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.35
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr614)
Anatomy Link Frequency
macrophages 1
Olr614 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 68 98.36 Very High Very High Very High
Inflammation 20 88.80 High High
methotrexate 41 87.40 High High
rheumatoid arthritis 17 63.44 Quite High
spinal inflammation 1 61.00 Quite High
cytokine 13 55.40 Quite High
imagery 13 22.56 Low Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 70 98.36 Very High Very High Very High
INFLAMMATION 19 88.80 High High
Injury 1 87.76 High High
Osteoporosis 2 86.88 High High
Hypercalcemia 2 85.84 High High
Autoimmune Disease 4 81.80 Quite High
Systemic Lupus Erythematosus 1 80.60 Quite High
Rheumatoid Arthritis 17 63.44 Quite High
Seronegative Spondarthritis 1 61.96 Quite High
Ankylosing Spondylitis 1 61.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because IgG2a is the most potent activator of the classical complement cascade and Fc receptor bearing macrophages, the present findings add further support to the inhibitory mechanism of T-614 and the pathogenic role of IgG2a in rat CIA [49].
Negative_regulation (mechanism) of T-614 in macrophages associated with arthritis
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.35 Pain Relevance 0.59

General Comments

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