INT264318

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.20
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr614)
Anatomy Link Frequency
body 1
Olr614 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 340 99.92 Very High Very High Very High
Inflammation 100 99.28 Very High Very High Very High
methotrexate 205 92.92 High High
imagery 65 92.72 High High
cytokine 65 80.60 Quite High
rheumatoid arthritis 85 77.68 Quite High
depression 5 58.52 Quite High
cINOD 5 41.48 Quite Low
COX-2 inhibitor 5 38.08 Quite Low
spinal inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 350 99.92 Very High Very High Very High
Experimental Arthritis 20 99.88 Very High Very High Very High
INFLAMMATION 95 99.28 Very High Very High Very High
Body Weight 20 98.92 Very High Very High Very High
Synovitis 5 96.32 Very High Very High Very High
Hyperplasia 10 90.84 High High
Immunization 30 90.40 High High
Pressure And Volume Under Development 135 88.00 High High
Stress 5 84.84 Quite High
Rheumatoid Arthritis 85 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunomodulatory effect of T-614 is not clear but it may partly depend on its inhibition of nuclear factor-?
Gene_expression (effect) of T-614
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.10 Pain Relevance 0.54
Induction of CIA in rats and T-614 treatment
Gene_expression (treatment) of T-614 associated with arthritis
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.65 Pain Relevance 0.19
Decrease in the development of collagen induced arthritis rats treated with T-614
Gene_expression (treated) of T-614 associated with experimental arthritis and arthritis
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.74 Pain Relevance 0.24
Decrease in the severity of inflammation in collagen induced arthritis rats treated with T-614
Gene_expression (treated) of T-614 associated with inflammation, experimental arthritis and arthritis
4) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.65 Pain Relevance 0.35
The rats received T-614 (daily dose 5 or 20 mg/kg body weight), nimesulide (Tocris Cookson, Ellisville, MO, USA; daily dose 10 mg/kg body weight), vehicle (0.5% CMC solution [vehicle] once daily), or MTX (Sigma, St.
Gene_expression (received) of T-614 in body associated with body weight and methotrexate
5) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.07 Pain Relevance 0.39

General Comments

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