INT264324

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr614)
Anatomy Link Frequency
lymph nodes 1
Olr614 (Rattus norvegicus)
IL-17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 40 100.00 Very High Very High Very High
cytokine 26 100.00 Very High Very High Very High
Arthritis 136 99.92 Very High Very High Very High
spinal inflammation 2 96.04 Very High Very High Very High
rheumatoid arthritis 34 80.68 Quite High
methotrexate 82 69.92 Quite High
imagery 26 55.84 Quite High
cINOD 2 44.48 Quite Low
COX-2 inhibitor 2 41.08 Quite Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 100.00 Very High Very High Very High
Arthritis 140 99.92 Very High Very High Very High
Disease 26 96.76 Very High Very High Very High
Ankylosing Spondylitis 2 96.16 Very High Very High Very High
Seronegative Spondarthritis 2 94.96 High High
Hyperplasia 4 93.84 High High
Osteoporosis 4 93.40 High High
Immunization 12 91.36 High High
Rheumatoid Arthritis 34 80.68 Quite High
Pressure And Volume Under Development 54 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrate the powerful inhibitory and dose-dependent effect of T-614 on IL-17 levels in local lymph nodes.
T-614 Regulation (effect) of IL-17 in lymph nodes
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.29 Pain Relevance 0.58
Modulation of inflammatory cytokines and IL-17 by T-614 suggests its potential therapeutic value in the treatment of other inflammatory diseases, such as ankylosing spondylitis and psoriatic arthritis.
T-614 Regulation (Modulation) of IL-17 associated with seronegative spondarthritis, spinal inflammation, inflammation, ankylosing spondylitis, disease, arthritis and cytokine
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.01 Pain Relevance 0.45

General Comments

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