INT264332

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr614)
Anatomy Link Frequency
CII 2
Olr614 (Rattus norvegicus)
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 68 89.88 High High
spinal inflammation 1 87.68 High High
Inflammation 20 86.04 High High
cytokine 13 82.08 Quite High
methotrexate 41 81.52 Quite High
rheumatoid arthritis 17 16.16 Low Low
imagery 13 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 1 96.68 Very High Very High Very High
Autoimmune Disease 4 96.08 Very High Very High Very High
Arthritis 70 89.88 High High
Seronegative Spondarthritis 1 88.64 High High
Ankylosing Spondylitis 1 87.68 High High
Disease 13 86.40 High High
INFLAMMATION 19 86.04 High High
Osteoporosis 2 74.04 Quite High
Hematological Disease 1 52.92 Quite High
Injury 1 40.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More interestingly, T-614 not only suppressed CII antibody levels but also differentially modulated immunoglobulin subclass levels; these effects suggest that it may be useful for the treatment of lupus or other autoimmune disorders.
T-614 Negative_regulation (suppressed) of Regulation (modulated) of immunoglobulin in CII associated with autoimmune disease and systemic lupus erythematosus
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.04 Pain Relevance 0.48

General Comments

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