INT264333

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.88
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) molecular_function (Mmp1a) cellular_component (Mmp1a)
biological_process (Mmp1a)
Anatomy Link Frequency
synovial cells 3
osteoblasts 1
IL-17 (Rattus norvegicus)
Mmp1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
rheumatoid arthritis 34 99.52 Very High Very High Very High
Arthritis 136 85.88 High High
cytokine 26 76.96 Quite High
Inflammation 40 66.52 Quite High
methotrexate 82 22.84 Low Low
imagery 26 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 99.52 Very High Very High Very High
Hypercalcemia 4 87.04 High High
Arthritis 140 85.88 High High
Experimental Arthritis 8 83.84 Quite High
Disease 26 78.92 Quite High
Congenital Anomalies 2 71.44 Quite High
Hyperplasia 4 68.64 Quite High
INFLAMMATION 38 66.52 Quite High
Autoimmune Disease 8 57.92 Quite High
Necrosis 6 42.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-17 also induces the expression of matrix metalloproteinase-1 and -13 in RA synovial cells and osteoblasts [15,16], and induces the expression of RANKL (receptor activator of nuclear factor-?
IL-17 Positive_regulation (induces) of Gene_expression (expression) of matrix metalloproteinase-1 in synovial cells associated with rheumatoid arthritis and metalloproteinase
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.44 Pain Relevance 0.59
IL-17 also induces the expression of matrix metalloproteinase-1 and -13 in RA synovial cells and osteoblasts [15,16], and induces the expression of RANKL (receptor activator of nuclear factor-?
IL-17 Positive_regulation (induces) of in osteoblasts Gene_expression (expression) of matrix metalloproteinase-1 in synovial cells associated with rheumatoid arthritis and metalloproteinase
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.44 Pain Relevance 0.59

General Comments

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