INT264337

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.28
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NCOA5)
Anatomy Link Frequency
skin 1
CII 1
NCOA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 317 100.00 Very High Very High Very High
Inflammation 92 100.00 Very High Very High Very High
Osteoarthritis 84 99.80 Very High Very High Very High
ketamine 3 69.76 Quite High
Pain 7 65.12 Quite High
depression 2 59.68 Quite High
imagery 29 51.60 Quite High
methotrexate 85 43.60 Quite Low
rheumatoid arthritis 60 36.88 Quite Low
Infliximab 2 34.08 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 333 100.00 Very High Very High Very High
Experimental Arthritis 10 100.00 Very High Very High Very High
Frailty 85 99.80 Very High Very High Very High
Immunization 42 91.24 High High
Disease 134 88.96 High High
Multiple Sclerosis 51 86.84 High High
Stress 4 86.00 High High
Weight Loss 10 83.44 Quite High
Osteoarthritis 4 80.72 Quite High
Pressure And Volume Under Development 72 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of this neoepitope were high a few weeks after an experimentally induced inflammatory arthritis (collagen induced arthritis, CIA) or OA (Song et al. 1999; Kojima et al. 2001; Chu et al. 2002; Kojima, 2004; Billinghurst et al. 2001).
Positive_regulation (induced) of CIA associated with inflammation, experimental arthritis, osteoarthritis and arthritis
1) Confidence 0.03 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.53 Pain Relevance 0.26
CIA was induced in female Wistar rats using a method described previously [24].
Positive_regulation (induced) of CIA associated with arthritis
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.60 Pain Relevance 0.19
Induction of CIA in rats and T-614 treatment
Positive_regulation (Induction) of CIA associated with arthritis
3) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.65 Pain Relevance 0.16
CIA was induced by injection of 0.4 ml emulsion into the dorsal skin distributed over four spots of 100 ?
Positive_regulation (induced) of CIA in skin associated with arthritis
4) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991037 Disease Relevance 0.46 Pain Relevance 0.19
To establish reproducibility of the induction protocol, ch-CII was selected for the third experiment (n = 6) - the most commonly used autoantigen for CIA induction in rodents.
Positive_regulation (induction) of CIA in CII associated with arthritis
5) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991037 Disease Relevance 1.54 Pain Relevance 0.22
Urinary excretion of the collagen crosslinks hydroxylysylpyrridinoline (HP) and lysylpyrridinoline (LP) were determined twice weekly, starting from the day of CIA induction.
Positive_regulation (induction) of CIA associated with arthritis
6) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991037 Disease Relevance 0.51 Pain Relevance 0.21

General Comments

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