INT264338

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.71
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocyte 3
IL-17 (Rattus norvegicus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 68 99.60 Very High Very High Very High
cytokine 13 90.68 High High
metalloproteinase 1 90.48 High High
rheumatoid arthritis 17 88.00 High High
Inflammation 20 80.24 Quite High
methotrexate 41 36.56 Quite Low
imagery 13 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 70 99.60 Very High Very High Very High
Disease 13 92.64 High High
Rheumatoid Arthritis 17 88.00 High High
Congenital Anomalies 1 85.16 High High
Hyperplasia 2 82.36 Quite High
INFLAMMATION 19 80.24 Quite High
Hypercalcemia 2 76.00 Quite High
Experimental Arthritis 4 72.80 Quite High
Autoimmune Disease 4 71.64 Quite High
Necrosis 3 56.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligation of the IL-17 receptor, which is expressed on several cell types (including epithelial cells, endothelial cells, and fibroblasts), induces the secretion of IL-6, IL-8, granulocyte colony-stimulating factor, monocyte chemotactic protein-1, prostaglandin E2, TNF-?
IL-17 Binding (Ligation) of in monocyte Positive_regulation (induces) of Localization (secretion) of TNF in monocyte
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.71 Pain Relevance 0.67

General Comments

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