INT26434

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Context Info
Confidence 0.81
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 8.67
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
nasal 3
epithelium 2
tubules 2
hepatocyte 1
kidney 1
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 26 98.80 Very High Very High Very High
Neuropeptide 21 98.72 Very High Very High Very High
Enkephalin 15 98.14 Very High Very High Very High
Dorsal horn 1 97.24 Very High Very High Very High
bradykinin 3 94.72 High High
Central nervous system 2 92.28 High High
Opioid 2 85.92 High High
Spinal cord 5 81.96 Quite High
Delta opioid receptors 2 79.48 Quite High
Pain 1 77.60 Quite High
Disease Link Frequency Relevance Heat
Renal Cancer 78 100.00 Very High Very High Very High
Cancer 348 99.68 Very High Very High Very High
Epstein-barr Virus 30 99.68 Very High Very High Very High
Prostate Cancer 54 99.40 Very High Very High Very High
Diabetes Mellitus 3 99.04 Very High Very High Very High
Injury 3 98.68 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 98.64 Very High Very High Very High
Hemangiosarcoma 4 96.92 Very High Very High Very High
Mantle-cell Lymphoma 33 96.72 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human nasal mucosal neutral endopeptidase (NEP): location, quantitation, and secretion.
Localization (secretion) of NEP in nasal
1) Confidence 0.81 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 8217197 Disease Relevance 0 Pain Relevance 0.13
Albrecht et al. [19] have reported a shift from membrane bound to cytoplasmic localization for CD10 in high-grade prostate cancer cells with a loss of CD10 expression in areas of high proliferative activity as indicated by Ki67 immunohistochemistry (n = 24, with perhaps around 7 containing CD10+ cancer cells based on their frequency).
Localization (localization) of CD10 associated with cancer and prostate cancer
2) Confidence 0.79 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.80 Pain Relevance 0
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Localization (localization) of NEP in epithelium associated with neuropeptide and substance p
3) Confidence 0.79 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.54 Pain Relevance 0.39
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Localization (localization) of neutral endopeptidase in epithelium associated with neuropeptide and substance p
4) Confidence 0.79 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.54 Pain Relevance 0.39
DPP IV and NEP activities were markedly decreased in all tumor subtypes, and protein and mRNAs were strongly down-regulated in ChRCC and RO.
Localization (decreased) of NEP associated with cancer
5) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.84 Pain Relevance 0
NEP activity in human nasal secretions obtained after normal saline challenge was 0.15 +/- 0.06 pmol/min/ml.
Localization (secretions) of NEP in nasal
6) Confidence 0.70 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0 Pain Relevance 0.13
Human nasal mucosal neutral endopeptidase (NEP): location, quantitation, and secretion.
Localization (secretion) of neutral endopeptidase in nasal
7) Confidence 0.70 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 8217197 Disease Relevance 0 Pain Relevance 0.13
Albrecht et al. [19] have reported a shift from membrane bound to cytoplasmic localization for CD10 in high-grade prostate cancer cells with a loss of CD10 expression in areas of high proliferative activity as indicated by Ki67 immunohistochemistry (n = 24, with perhaps around 7 containing CD10+ cancer cells based on their frequency).
Localization (localization) of CD10 associated with cancer and prostate cancer
8) Confidence 0.70 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.80 Pain Relevance 0
In addition to the modulating functions of NEP on neuropeptide-mediated activities on vessels and glands, it is possible that NEP in secretions plays a role in regulating mucosal responses to luminal neuropeptides or other as yet uncharacterized NEP substrates.
Localization (secretions) of NEP in glands associated with neuropeptide
9) Confidence 0.66 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0.07 Pain Relevance 0.10
Kininase I, II and neutral endopeptidase (enkephalinase) are localized not only in the proximal tubules, but also in the distal tubules.
Localization (localized) of enkephalinase in tubules
10) Confidence 0.64 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2557757 Disease Relevance 0 Pain Relevance 0
In order to confirm the existence of NEP in the human respiratory mucosa, inferior nasal turbinate mucosae obtained at surgery and nasal secretions induced by topical provocations with methacholine, histamine, and allergen were analyzed for: (1) NEP activity (pmol product/min/ml) by enzymatic degradation of [3H]leu-enkephalin, (2) the presence of NEP-immunoreactive material by Western blot analysis, and (3) cellular localization of NEP distribution by immunohistochemistry.
Localization (localization) of NEP in inferior associated with enkephalin
11) Confidence 0.62 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0 Pain Relevance 0.14
NEP and delta binding sites were localized transiently in the fasciculus gracilis at the cervical level at a fetal age of 24 weeks, an area where no enkephalin-like immunoreactivity (ELI) has been found.
Localization (localized) of NEP in gracilis associated with enkephalin
12) Confidence 0.62 Published 1989 Journal J. Chem. Neuroanat. Section Abstract Doc Link 2557052 Disease Relevance 0.08 Pain Relevance 0.53
DPPIV and NEP immunostaining distribution in renal tumours and normal kidney is presented in Table 2 and in Figures 5, 6 and 7.
Localization (presented) of NEP in kidney associated with renal cancer
13) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.48 Pain Relevance 0
We have previously demonstrated increased NEP localization and enzyme activity in diabetic wounds and skin compared with normal controls.
Localization (localization) of NEP in skin associated with diabetes mellitus and injury
14) Confidence 0.61 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.74 Pain Relevance 0.19
Kininase I, II and neutral endopeptidase (enkephalinase) are localized not only in the proximal tubules, but also in the distal tubules.
Localization (localized) of neutral endopeptidase in tubules
15) Confidence 0.56 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2557757 Disease Relevance 0 Pain Relevance 0
The tumor cells were negative for CD34, CK20, alpha-fetoprotein, placental-like alkaline phosphatase, hepatocyte paraffin 1, polyclonal carcinoembryonic antigen, CD10, CA-125, prostate-specific antigen, and prostatic acid phosphatase.
Localization (like) of CD10 in hepatocyte associated with cancer
16) Confidence 0.45 Published 2010 Journal Diagn. Cytopathol. Section Abstract Doc Link 19813270 Disease Relevance 0.95 Pain Relevance 0.08
In addition to the modulating functions of NEP on neuropeptide-mediated activities on vessels and glands, it is possible that NEP in secretions plays a role in regulating mucosal responses to luminal neuropeptides or other as yet uncharacterized NEP substrates.
Localization (secretions) of NEP in vessels associated with neuropeptide
17) Confidence 0.22 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0.07 Pain Relevance 0.10
In BL, a homogeneous phenotype (CD10(+), BCL6(+), Bcl-2(?)
Localization (phenotype) of CD10 associated with epstein-barr virus
18) Confidence 0.13 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 2.74 Pain Relevance 0

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