INT264380

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) Golgi apparatus (MMP13) DNA binding (JUN) cytosol (JUN)

JUN (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 50.00 agonist 1 50.00 Inflammatory stimuli 1 6.64 Inflammation 9 5.00 cytokine 6 5.00 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 6.32 Syndrome 6 5.00 Chondrosarcoma 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

to the DR-1 elements in the MMP-1 and MMP-13 promoters, thereby displacing AP-1 transcription factors and causing greater inhibition of mRNA production.

AP-1 Binding (displacing) of MMP-13

1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

General Comments

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