INT264393

Context Info Confidence 0.29 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.04

peptidase activity (MMP1, MMP13) extracellular region (MMP1, MMP13) proteinaceous extracellular matrix (MMP1, MMP13) extracellular space (MMP13) Golgi apparatus (MMP13) lysosome (MMP13)

MMP1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 9 82.56 metalloproteinase 14 50.00 agonist 1 50.00 cytokine 6 5.00 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 82.56 Repression 3 60.92 Syndrome 6 5.00 Chondrosarcoma 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced MMP-1 and MMP-13 expression by LG268 requires 12 to 24 hours of pretreatment with LG268 prior to the addition of IL-1?

MMP-1 Positive_regulation (requires) of Gene_expression (expression) of MMP-13

1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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