INT264399

Context Info Confidence 0.39 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.13

extracellular space (IL1B, MMP13) extracellular region (IL1B, MMP13) aging (IL1B) Golgi apparatus (MMP13) cell-cell signaling (IL1B) cytosol (IL1B)

IL1B (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 88.80 Inflammatory stimuli 1 84.92 agonist 1 50.00 cytokine 6 49.56 Inflammation 9 49.20 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 84.60 Chondrosarcoma 6 47.68 Syndrome 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The maximum expression of MMP-1 and MMP-13 mRNA with rosiglitazone treatment is approximately 50% of that seen with IL-1?

IL-1 Binding (seen) of MMP-13

1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

This test has worked.