INT2644

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Context Info
Confidence 0.54
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Kalrn) intracellular (Kalrn) cytoplasm (Kalrn)
Anatomy Link Frequency
smooth muscle 1
gastric fundus 1
Kalrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C inhibitor 1 94.88 High High
Enkephalin 5 90.28 High High
Opioid 2 89.08 High High
cva 8 81.52 Quite High
antagonist 1 77.84 Quite High
qutenza 2 25.00 Low Low
agonist 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 5 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 9 82.56 Quite High
Cv General 3 Under Development 2 81.52 Quite High
Cv General 4 Under Development 6 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Hypercapnia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Spasticity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using reverse transcription-polymerase chain reaction techniques, it was observed that the mRNA for the TRPM8 receptor and Rho-kinase were expressed in the rat gastric fundus. 6.
Gene_expression (expressed) of Rho-kinase in gastric fundus
1) Confidence 0.54 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16173944 Disease Relevance 0 Pain Relevance 0.09
The COOH-terminal tetrapeptide is not adsorbed and, since it carries the radioactive label, is easily assayed in the charcoal-free supernatant fluid.
Gene_expression (assayed) of COOH-terminal
2) Confidence 0.46 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 489604 Disease Relevance 0 Pain Relevance 0.46
In conclusion, our results indicate that both endogenous TXA2 production and hypersensitivity of the TP-receptors and/or the Rho-kinase signaling pathway in the cerebrovascular smooth muscle contribute to the development of CBF oscillations after NO synthase blockade.
Gene_expression (production) of Rho-kinase in smooth muscle associated with hypersensitivity
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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