INT264402

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.11

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

MMP2 (Homo sapiens) MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 82.44 Inflammatory stimuli 1 57.20 agonist 1 50.00 cytokine 6 21.84 Inflammation 9 21.48 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 56.88 Chondrosarcoma 6 19.96 Syndrome 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

induction of MMP-1 and MMP-13 while having either a very modest effect (MMP-9) or no effect (MMP-2, MMP-3, and MMP-14) on other MMP family members (Figure 2).

MMP-2 Neg (no) Regulation (effect) of MMP-14

1) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

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