INT264407

Context Info Confidence 0.08 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0

Golgi apparatus (MMP13) intracellular (DR1) DNA binding (DR1) peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13)

Anatomy Link Frequency proximal 2 DR1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 42 50.00 agonist 3 50.00 Arthritis 9 19.44 Inflammation 27 5.00 cytokine 18 5.00 rheumatoid arthritis 15 5.00 Osteoarthritis 15 5.00 Pain 3 5.00 Inflammatory stimuli 3 5.00 Immobilon 3 5.00

Disease Link Frequency Relevance Heat Arthritis 15 19.44 Chondrosarcoma 18 12.44 Repression 9 9.20 INFLAMMATION 30 5.00 Syndrome 18 5.00 Osteoarthritis 15 5.00 Rheumatoid Arthritis 15 5.00 Diabetes Mellitus 6 5.00 Cancer 6 5.00 Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

binding at the DR-1/AP-1 site of the endogenous MMP-1 and MMP-13 promoters in genomic DNA.

DR-1/AP-1 Binding (binding) of MMP-13

1) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

were binding to the DR-1/AP-1 site in the MMP-1 and MMP-13 proximal promoters, this DNA element may also be responsive to treatment with combinations of LG268 and rosiglitazone.

DR-1/AP-1 Binding (binding) of MMP-13 in proximal

2) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

were binding to the DR-1/AP-1 site in the MMP-1 and MMP-13 proximal promoters, this DNA element may also be responsive to treatment with combinations of LG268 and rosiglitazone.

DR-1/AP-1 Binding (binding) of MMP-13 in proximal

3) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

General Comments

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