INT264435

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.46
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R2) plasma membrane (IL1R2)
Anatomy Link Frequency
chondrocytes 2
IL1R2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Inflammation 15 98.60 Very High Very High Very High
Osteoarthritis 5 93.92 High High
rheumatoid arthritis 8 93.36 High High
metalloproteinase 14 90.24 High High
agonist 1 50.00 Quite Low
Pain 1 48.24 Quite Low
Tendonitis 1 46.48 Quite Low
Arthritis 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 99.00 Very High Very High Very High
Cancer 2 98.96 Very High Very High Very High
INFLAMMATION 17 98.60 Very High Very High Very High
Necrosis 1 98.48 Very High Very High Very High
Arthropathy 2 94.04 High High
Osteoarthritis 5 93.92 High High
Takayasu Arteritis 50 93.56 High High
Rheumatoid Arthritis 11 93.36 High High
Hypertrophy 1 92.72 High High
Arthritis 5 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability to cleave the collagen triple helix is unique to the collagenases, and the overexpression of MMP-1 and MMP-13 in chondrocytes in response to proinflammatory cytokines such as interleukin-1-beta (IL-1?)
Positive_regulation (response) of Gene_expression (cytokines) of interleukin-1-beta in chondrocytes associated with cytokine
1) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 1.27 Pain Relevance 0.47
Enhanced expression of IL-1 receptor, type II (IL-1R2), a decoy receptor that traps pro-inflammatory IL-1?
Positive_regulation (Enhanced) of Gene_expression (expression) of IL-1R2 associated with inflammation and tumor necrosis factor receptor-associated periodic syndrome
2) Confidence 0.02 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 1.19 Pain Relevance 0.23

General Comments

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