INT264448

Context Info Confidence 0.47 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.38 Pain Relevance 0.16

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12 83.80 Inflammation 18 83.44 Inflammatory stimuli 2 68.24 metalloproteinase 28 50.00 agonist 2 50.00 Arthritis 6 27.88 rheumatoid arthritis 10 5.00 Osteoarthritis 10 5.00 Pain 2 5.00 Immobilon 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 20 83.44 Chondrosarcoma 12 81.92 Arthritis 10 27.88 Arthropathy 4 26.68 Syndrome 12 5.00 Osteoarthritis 10 5.00 Rheumatoid Arthritis 10 5.00 Repression 6 5.00 Diabetes Mellitus 4 5.00 Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, and RXR homodimers bind to the DR-1 element [11], suggesting that all or any of these three dimers may be responsible for mediating the inhibitory effect of LG268 on MMP-1 and MMP-13.

Positive_regulation (mediating) of Negative_regulation (effect) of MMP-13

1) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.15 Pain Relevance 0.04

and LG268 leads to modest but significant inhibition of MMP-1 and MMP-13, and a 12- to 24-hour pretreatment is necessary for maximum inhibition of MMP levels in these cells by the RXR ligand, LG268 [21].

Positive_regulation (leads) of Negative_regulation (inhibition) of MMP-13

2) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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